Use the help (?) options in the Adwords system. It is your friend and will help you.

But the quality score is affected by how your keyword, your ad, and your landing page work together. If you put all your keywords in one adgroup, it will be hard to have a good quality score.

Take your keyword list and make a number of categories. Then make an adgroup for each category. Under each adgroup, create ads just for that adgroup. Then if you have some more general ads you can include them as well and Google will let you know what ads and keywords work well.

And don't forget that you can increase your bids to get your ads to place higher on the page...! ;-)